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      Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.

      Antimicrobial Agents and Chemotherapy

      genetics, Anti-Bacterial Agents, Bacterial Proteins, metabolism, drug effects, Drug Resistance, Multiple, Bacterial, Erythromycin, Streptococcus pyogenes, pharmacology, Tetracycline Resistance, Lysogeny

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          Abstract

          We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-dependent barrier to lysogenic transfer was not observed. The emm12 strains were the only strains susceptible to the lytic action of the bacteriophage preparation.

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          Journal
          20643900
          2944561
          10.1128/AAC.01318-09

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