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      Stromal cell contributions to the homeostasis and functionality of the immune system.

      1 ,
      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective development of adaptive immune responses take place. What has only recently been recognized is the role that non-haematopoietic stromal elements have in many aspects of immune cell migration, activation and survival. In this Review, we summarize our current understanding of lymphoid compartment stromal cells, examine their possible heterogeneity, discuss how these cells contribute to immune homeostasis and the efficient initiation of adaptive immune responses, and highlight how targeting of these elements by some pathogens can influence the host immune response.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Sep 2009
          : 9
          : 9
          Affiliations
          [1 ] Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia. smue@unimelb.edu.au
          Article
          nri2588 NIHMS156930
          10.1038/nri2588
          2785037
          19644499
          d5e9a821-f7ef-40df-8e7c-f0484d842dd2
          History

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