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      Atypical fibroxanthoma: new insights.

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          Abstract

          Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. It occurs on sun-exposed skin of elderly peoples. AFX may be composed predominantly of pleomorphic, spindle, epithelioid cells, or admixture of these cells. The differential diagnosis of AFX includes pleomorphic dermal sarcoma, squamous cell carcinoma, malignant melanoma and leiomyosarcoma. Several observations favor a mesenchymal origin for AFX. These reviews address the clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm.

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          Author and article information

          Journal
          Expert Rev Anticancer Ther
          Expert review of anticancer therapy
          Informa UK Limited
          1744-8328
          1473-7140
          Sep 2014
          : 14
          : 9
          Affiliations
          [1 ] Department of Pathology, Faculty of Medicine and Assuit University Hospitals, Assiut University, Assiut, Egypt.
          Article
          10.1586/14737140.2014.924401
          24958232

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