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      Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.

      1 ,
      Nature reviews. Drug discovery
      Springer Science and Business Media LLC

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          Abstract

          Nuclear factor kappaB (NF-kappaB) transcription factors have a key role in many physiological processes such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF-kappaB and the signalling pathways that control its activity are involved in cancer development and progression, as well as in resistance to chemotherapy and radiotherapy. This article discusses recent evidence from cancer genetics and cancer genome studies that support the involvement of NF-kappaB in human cancer, particularly in multiple myeloma. The therapeutic potential and benefit of targeting NF-kappaB in cancer, and the possible complications and pitfalls of such an approach, are explored.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1784
          1474-1776
          Jan 2009
          : 8
          : 1
          Affiliations
          [1 ] Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014, Paris, France. veronique.baud@inserm.fr
          Article
          nrd2781 HALMS352349
          10.1038/nrd2781
          2729321
          19116625
          d5fca6b8-330f-495c-a54d-ced75bcd668f
          History

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