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      NF-kappaB in cancer: from innocent bystander to major culprit.

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          Abstract

          Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Apr 2002
          : 2
          : 4
          Affiliations
          [1 ] Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093, USA. karinoffice@ucsd.edu
          Article
          10.1038/nrc780
          12001991
          d60fdcf7-403a-42d9-ae2b-4e9ffd9222b0
          History

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