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      NF-kappaB in cancer: from innocent bystander to major culprit.

      Nature reviews. Cancer

      Signal Transduction, Humans, Lymphatic Diseases, metabolism, Models, Biological, NF-kappa B, biosynthesis, Neoplasms, Animals

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          Abstract

          Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.

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          Journal
          12001991
          10.1038/nrc780

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