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      The effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity.

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          Abstract

          To examine the fetal programming effects of maternal hypertension, natriophilia and hyperreninemia [experimentally induced in rats by partial inter-renal aortic ligature (PAL) prior to mating] fos immunoreactivity was studied in 6-day-old offspring of PAL and control mothers. The purposes of the present set of experiments were twofold. The first was to characterize the effects of PAL on the mother's arterial blood pressure and intake of salt (1.8% NaCl solution) and water over the course of gestation. Second, was to study the pattern of neuronal activation in key brain areas of 6-day-old offspring treated with the dipsogen isoproterenol that were from PAL and control mothers. Beta-adrenergic receptor agonist-treated pups allowed the determination whether there were neuroanatomical correlates within the neural substrates controlling thirst and the enhanced water intake evidenced by the isoproterenol treated pups of PAL mothers. Hydromineral ingestive behavior along with blood pressure and heart rate of PAL (M-PAL) and control (M-sPAL) dams throughout gestation was studied. Higher salt and water intakes along with blood pressures and heart rates were found during gestation and lactation in the M-PAL group. Maternal PAL evoked significantly increased isoproterenol-elicited Fos staining in brain regions (e.g. subfornical organ, organum vasculosum of the lamina terminalis, supraoptic nucleus, hypothalamic paraventricular nucleus and median preoptic nucleus) of 6-day-old pups, which is the age of animals shown enhanced thirst responses in PAL offspring. These results indicate that PAL is compatible with pregnancy, producing a sustained increase in blood pressure and heart rate, along with increased water and salt intake. The present study demonstrates that the neural substrates involved in cardiovascular homeostasis and fluid balance in adult rats are responsive in six-day-old rats, and can be altered by fetal programming.

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          Author and article information

          Journal
          Appetite
          Appetite
          Elsevier BV
          1095-8304
          0195-6663
          September 01 2017
          : 116
          Affiliations
          [1 ] Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Spain. Electronic address: jal@uniovi.es.
          [2 ] Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Spain.
          [3 ] Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, 52242, USA.
          [4 ] Currently at Departamento de Fisiologia, Centro C. Biológicas e Saúde, Universidade Federal de Sergipe, Sau Cristovao, SE, Brazil.
          [5 ] Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago de Chile, Chile.
          Article
          S0195-6663(16)30820-0
          10.1016/j.appet.2017.04.008
          28411128
          d63d2a14-165c-4aea-babe-28b9d136865b
          History

          Thirst,Renin-angiotensin-aldosterone system,Ontogeny,Isoproterenol,Hypertension,Gestation,c-Fos

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