Bibliometric analysis of global scientific activity on umbilical cord mesenchymal stem cells: a swiftly expanding and shifting focus

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Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis evaluating the evolution in UC-MSC research. Therefore, this study aimed to assess scientific activity regarding UC-MSC research. Publications on UC-MSCs were retrieved from the Science Citation Index-Expanded (SCI-E) of the Web of Science (WoS) from 1975 to 2017. Statistical analyses were performed using Excel, GraphPad Prism 5, and VOSviewer software. Comparative analyses were employed to assess contributions between different countries, institutes, and researchers. With 21.26 citations per paper, 1206 papers cited 25,517 times were included. Mainland China contributed the most with 558 papers, with the most citations (6858 times) and the highest H-index (43). South Korea ranked first for number of papers per million people and per trillion gross domestic product (GDP). Keywords were stratified into two clusters by VOSviewer software: cluster 1, “treatments and effects”; and cluster 2, “characteristics”. The average appearing years (AAY) of keywords in cluster 1 was more recent than that in cluster 2. For promising hotspots, “TNF-α” showed the latest AAY at 2014.09, followed by “migration”, “angiogenesis”, and “apoptosis”. We conclude that the number of publications has been continuously growing dramatically since 2002 and that mainland China and South Korea are the most productive regions. The focus gradually shifts from “characteristics” to “treatments and effects”. Attention should be drawn to the latest hotspots, such as “TNF-α”, “migration”, “angiogenesis”, and “apoptosis”. Furthermore, funding agencies might increase investments in exploring the therapeutic potential of UC-MSCs.

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Most cited references 45

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Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway.

Bin Zhang, Xiaodan Wu, Xu Zhang … (2015)

Human umbilical cord mesenchymal stem cells (hucMSCs) and their exosomes have been considered as potential therapeutic tools for tissue regeneration; however, the underlying mechanisms are still not well understood. In this study, we isolated and characterized the exosomes from hucMSCs (hucMSC-Ex) and demonstrated that hucMSC-Ex promoted the proliferation, migration, and tube formation of endothelial cells in a dose-dependent manner. Furthermore, we demonstrated that hucMSC-Ex promoted wound healing and angiogenesis in vivo by using a rat skin burn model. We discovered that hucMSC-Ex promoted β-catenin nuclear translocation and induced the increased expression of proliferating cell nuclear antigen, cyclin D3, N-cadherin, and β-catenin and the decreased expression of E-cadherin. The activation of Wnt/β-catenin is critical in the induction of angiogenesis by hucMSC-Ex, which could be reversed by β-catenin inhibitor ICG-001. Wnt4 was delivered by hucMSC-Ex, and the knockdown of Wnt4 in hucMSC-Ex abrogated β-catenin nuclear translocation in endothelial cells. The in vivo proangiogenic effects were also inhibited by interference of Wnt4 expression in hucMSC-Ex. Taken together, these results suggest that hucMSC-Ex-mediated Wnt4 induces β-catenin activation in endothelial cells and exerts proangiogenic effects, which could be an important mechanism for cutaneous wound healing.

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Exosomes Derived from Akt‐Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet‐Derived Growth Factor D

Jie Ma, Yuanyuan Zhao, Li Sun … (2016)

Abstract We have previously demonstrated the cardioprotective effects of exosomes derived from mesenchymal stem cells (MSCs). It is well known that the activation of Akt is involved in stem cell‐induced cardioprotection. In the present study, we investigated whether exosomes released from Akt‐overexpressing MSCs showed a beneficial effect on cardioprotection and angiogenesis. MSCs were collected from human umbilical cord (hucMSCs), and Akt was transfected into hucMSCs (Akt‐hucMSCs) by using an adenovirus transfection system. Exosomes were isolated from control hucMSCs (Exo) and Akt‐hucMSCs (Akt‐Exo). An acute myocardial infarction model was created by ligation of the left anterior decedent coronary artery (LAD) in rats. Various source exosomes (400 µg of protein) were infused via the tail vein immediately after LAD ligation. The cardiac function was evaluated by using echocardiography after different treatments for 1 and 5 weeks, respectively. Endothelial cell proliferation, migration, and tube‐like structure formation, as well as chick allantoic membrane assay, were used to evaluate the angiogenetic effects of Akt‐Exo. The results indicated that cardiac function was significantly improved in the animals treated with Akt‐Exo. In addition, Akt‐Exo significantly accelerated endothelial cell proliferation and migration, tube‐like structure formation in vitro, and blood vessel formation in vivo. The expression of platelet‐derived growth factor D (PDGF‐D) was significantly upregulated in Akt‐Exo. However, the angiogenesis was abrogated in endothelial cells treated with the exosomes obtained from MSCs transfected with PDGF‐D‐siRNA. Our studies suggest that exosomes obtained from Akt‐modified hucMSCs are more effective in myocardial infarction therapy through promoting angiogenesis. PDGF‐D plays an important role in Akt‐Exo‐mediated angiogenesis. Stem Cells Translational Medicine 2017;6:51–59

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Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain.

Brian White, S Bagley, B Golomb (2001)

Logistic regression (LR) is a widely used multivariable method for modeling dichotomous outcomes. This article examines use and reporting of LR in the medical literature by comprehensively assessing its use in a selected area of medical study. Medline, followed by bibliography searches, identified 15 peer-reviewed English-language articles with original data, employing LR, published between 1985 and 1999, pertaining to patient interest in genetic testing for cancer susceptibility. Articles were examined for each of 10 criteria for proper use and reporting of LR models. Substantial shortcomings were found in both use of LR and reporting of results. For many studies, the ratio of the number of outcome events to predictor variables (events per variable) was sufficiently small to call into question the accuracy of the regression model. Additionally, no studies reported validation analysis, regression diagnostics, or goodness-of-fit measures. It is recommended that authors, reviewers, and editors pay greater attention to guidelines concerning the use and reporting of LR models.

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Author and article information

Contributors

Jian Zhao: zhaojiansmmu@sina.cn

Guanyu Yu: yuguanyu0451@163.com

Mengxi Cai: 906650016@qq.com

Xiao Lei: 1861758966@163.com

Yanyong Yang: yyyang2010@163.com

Qijin Wang: wangqijin8668601@163.com

Xiao Zhai: zhaixiao@smmu.edu.cn

Journal

Journal ID (nlm-ta): Stem Cell Res Ther

Journal ID (iso-abbrev): Stem Cell Res Ther

Title: Stem Cell Research & Therapy

Publisher: BioMed Central (London )

ISSN (Electronic): 1757-6512

Publication date (Electronic): 7 February 2018

Publication date PMC-release: 7 February 2018

Publication date Collection: 2018

Volume: 9

Electronic Location Identifier: 32

Affiliations

[1 ]ISNI 0000 0004 0369 1660, GRID grid.73113.37, Department of Orthopedics, Changhai Hospital, , Second Military Medical University, ; Shanghai, China

[2 ]ISNI 0000 0004 0369 1660, GRID grid.73113.37, Graduate Management Unit, , Second Military Medical University, ; Shanghai, China

[3 ]ISNI 0000 0004 0369 1660, GRID grid.73113.37, Department of Colorectal Surgery, Changhai Hospital, , Second Military Medical University, ; Shanghai, China

[4 ]ISNI 0000 0004 0369 1660, GRID grid.73113.37, Department of Radiation Medicine, Faculty of Naval Medicine, , Second Military Medical University, ; Shanghai, 200433 China

[5 ]ISNI 0000 0004 0369 1660, GRID grid.73113.37, Department of Endocrinology, Changhai Hospital, , Second Military Medical University, ; Shanghai, 200433 China

Article

Publisher ID: 785

DOI: 10.1186/s13287-018-0785-5

PMC ID: 5803908

PubMed ID: 29415771

SO-VID: d6416edc-c4a5-4b0c-af19-e694a83b8967

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Funding

Funded by: Foundation of Changhai Hospital

Award ID: CH201717

Award Recipient : Xiao Zhai

Funded by: National Natural Science Foundation of China

Award ID: 81701199

Award Recipient : Jian Zhao

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 81601953

Award ID: 81670741

Award Recipient : Jian Zhao

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ScienceOpen disciplines: Molecular medicine

Keywords: bibliometric,citation,h-index,uc-msc,hotspots

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ScienceOpen disciplines: Molecular medicine

Keywords: bibliometric, citation, h-index, uc-msc, hotspots

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Bibliometric analysis of global scientific activity on umbilical cord mesenchymal stem cells: a swiftly expanding and shifting focus

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Most cited references 45

Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway.

Exosomes Derived from Akt‐Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet‐Derived Growth Factor D

Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain.

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