1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Higher dietary intake of vitamin D may influence total cholesterol and carbohydrate profile independent of body composition in men with Chronic Spinal Cord Injury

      1 , 2 , 1 , 2 , 1 , 1 , 3 , 4 , 5
      The Journal of Spinal Cord Medicine
      Informa UK Limited

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          <div class="section"> <a class="named-anchor" id="d8902341e173"> <!-- named anchor --> </a> <h5 class="section-title" id="d8902341e174">Study Design</h5> <p id="d8902341e176">A case-control design.</p> </div><div class="section"> <a class="named-anchor" id="d8902341e178"> <!-- named anchor --> </a> <h5 class="section-title" id="d8902341e179">Objectives</h5> <p id="d8902341e181">To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). </p> </div><div class="section"> <a class="named-anchor" id="d8902341e183"> <!-- named anchor --> </a> <h5 class="section-title" id="d8902341e184">Methods</h5> <p id="d8902341e186">20 male, paraplegic (T3-L1) with chronic (&gt; one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution. Individuals in both groups were matched based on age, weight, time since injury and level of injury. Sg, Si and lipid profiles were measured of the two groups. </p> </div><div class="section"> <a class="named-anchor" id="d8902341e188"> <!-- named anchor --> </a> <h5 class="section-title" id="d8902341e189">Results</h5> <p id="d8902341e191">The high vitamin D group had an average intake of 5.33 ± 4.14 mcg compared to low vitamin D group, 0.74 ± 0.24 mcg. None of the 20 participants met the recommended guidelines for daily vitamin D intake. The higher vitamin D group had a significantly lower ( <i>P</i> = 0.035) total cholesterol (148.00 ± 14.12 mg/dl) than the lower vitamin D group (171.80 ± 36.22 mg/dl). Vitamin D adjusted to total dietary intake was positively correlated to improvement in Si and Sg ( <i>P</i>&lt;0.05). </p> </div><div class="section"> <a class="named-anchor" id="d8902341e199"> <!-- named anchor --> </a> <h5 class="section-title" id="d8902341e200">Conclusion</h5> <p id="d8902341e202">The findings suggest that persons with SCI consume much less than the recommended guidelines for daily vitamin D intake. However, a higher dietary intake of vitamin D may influence total cholesterol and carbohydrate profile as demonstrated by a significant decrease in total cholesterol and improvement in glucose homeostasis independent of body composition changes after SCI. </p> </div>

          Related collections

          Most cited references39

          • Record: found
          • Abstract: found
          • Article: not found

          General cardiovascular risk profile for use in primary care: the Framingham Heart Study.

          Separate multivariable risk algorithms are commonly used to assess risk of specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure. The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents. We used Cox proportional-hazards regression to evaluate the risk of developing a first CVD event in 8491 Framingham study participants (mean age, 49 years; 4522 women) who attended a routine examination between 30 and 74 years of age and were free of CVD. Sex-specific multivariable risk functions ("general CVD" algorithms) were derived that incorporated age, total and high-density lipoprotein cholesterol, systolic blood pressure, treatment for hypertension, smoking, and diabetes status. We assessed the performance of the general CVD algorithms for predicting individual CVD events (coronary heart disease, stroke, peripheral artery disease, or heart failure). Over 12 years of follow-up, 1174 participants (456 women) developed a first CVD event. All traditional risk factors evaluated predicted CVD risk (multivariable-adjusted P<0.0001). The general CVD algorithm demonstrated good discrimination (C statistic, 0.763 [men] and 0.793 [women]) and calibration. Simple adjustments to the general CVD risk algorithms allowed estimation of the risks of each CVD component. Two simple risk scores are presented, 1 based on all traditional risk factors and the other based on non-laboratory-based predictors. A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure). The estimated absolute CVD event rates can be used to quantify risk and to guide preventive care.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial.

            Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate with increased risk of type 2 diabetes. Small, observational studies suggest an action for vitamin D in improving insulin sensitivity and/or insulin secretion. The objective of the present study was to investigate the effect of improved vitamin D status on insulin resistance (IR), utilising randomised, controlled, double-blind intervention administering 100 microg (4000 IU) vitamin D(3) (n 42) or placebo (n 39) daily for 6 months to South Asian women, aged 23-68 years, living in Auckland, New Zealand. Subjects were insulin resistant - homeostasis model assessment 1 (HOMA1)>1.93 and had serum 25(OH)D concentration 25 microg (1000 IU)/d. The HOMA2 computer model was used to calculate outcomes. Median (25th, 75th percentiles) serum 25(OH)D(3) increased significantly from 21 (11, 40) to 75 (55, 84) nmol/l with supplementation. Significant improvements were seen in insulin sensitivity and IR (P = 0.003 and 0.02, respectively), and fasting insulin decreased (P = 0.02) with supplementation compared with placebo. There was no change in C-peptide with supplementation. IR was most improved when endpoint serum 25(OH)D reached > or = 80 nmol/l. Secondary outcome variables (lipid profile and high sensitivity C-reactive protein) were not affected by supplementation. In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults.

                Bookmark

                Author and article information

                Journal
                The Journal of Spinal Cord Medicine
                The Journal of Spinal Cord Medicine
                Informa UK Limited
                1079-0268
                2045-7723
                September 06 2017
                July 04 2018
                August 16 2017
                July 04 2018
                : 41
                : 4
                : 459-470
                Affiliations
                [1 ] Spinal Cord Injury Service and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA
                [2 ] Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, Virginia, USA
                [3 ] Endocrinology Service, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA
                [4 ] Endocrinology Division, Virginia Commonwealth University, Richmond, Virginia, USA
                [5 ] Department of Physical Medicine and Rehabilitation, Milton S. Hershey Medical Center, Penn State University, Hershey, Pennsylvania, USA
                Article
                10.1080/10790268.2017.1361561
                6055974
                28812446
                d6417e6e-2568-49cc-9359-f2102cf1e980
                © 2018
                History

                Comments

                Comment on this article