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      Clinical Drug Investigation
      Springer International Publishing

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          Chronic venous insufficiency.

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            To be a great physician, you must understand the whole story.

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              Impact of chronic venous disease on quality of life: Results of vein alarm study

              Chronic venous disease (CVD) affects millions of people and negatively impacting the patient's quality of life (QoL) and most of the patients are diagnosed with CVD in advanced stages. The impact of newly diagnosed CVD on QoL has not been evaluated by other studies in Romania. The aim of this study was to assess the QoL for adult patients newly diagnosed with CVD addressing to the General Practitioner's (GP) office in Romania between June to August 2016. Patients included in the study were adult, signing the inform consent form, newly diagnosed with CVD or patients diagnosed with CVD, without CVD treatment the past 6 months. Data on demographic distribution, risk factors, clinical profiles, CVD symptomatology, QoL parameters, as well as pharmacological management practice were collected. The study included 1,893 patients (79.08% females) with 50.4% of patients in the age group 51–70 years. The most frequent CVD symptoms reported, were heavy leg sensation (85.74%), swelling of the feet (77.28%) and pain (73.11%). The most frequent CVD signs were telangiectasia and reticular veins (79.19%), varicose veins (65.77%) and edema (53.35%). The clinical, aetiological, anatomical and pathophysiological (CEAP) classification placed most of the patients in C3 class (31.85%), followed by C2 class (28.00%), C1 class (21.02%) and C4a (8.87%). Most of the patients reported ‘low’ or ‘moderate’ intensity of the CVD symptoms. QoL was affected for most of the patients at ‘a mild’ or ‘moderate’ degree, being noticed as a significant negative impact on physical, psychological, and social functioning components of QoL, correlated with CEAP class (P<0.001). Data regarding correlation of CEAP class, CVD symptoms and impact on QoL identified a significant correlation between all analyzed components (P<0.001). Study results prove that CVD diagnosis was established with relative delay and CVD is negatively affecting patients' QoL. Additional research will be needed to identify the long-term impact of CVD on QoL of the affected patients and their families.
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                Author and article information

                Contributors
                maleti@chirurgiavascolaremodena.com
                Journal
                Clin Drug Investig
                Clin Drug Investig
                Clinical Drug Investigation
                Springer International Publishing (Cham )
                1173-2563
                1179-1918
                12 May 2023
                12 May 2023
                2023
                : 43
                : Suppl 1
                : 1-2
                Affiliations
                GRID grid.414062.5, ISNI 0000 0004 1760 2091, Vascular Surgery, International Centre of Deep Venous Surgery, Cardiovascular Department, , Hesperia Hospital, ; Via Arquà 80, 41125 Modena, Italy
                Article
                1262
                10.1007/s40261-023-01262-x
                10220093
                37173529
                d64dfb14-8575-4837-99aa-3ec6c6443db2
                © The Author(s) 2023

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 23 March 2023
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100011725, Servier;
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                © Springer Nature Switzerland AG 2023

                Pharmacology & Pharmaceutical medicine
                Pharmacology & Pharmaceutical medicine

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