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      Molecular mechanisms of proliferation in endometrial tumour cells.

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          Abstract

          The human endometrium normally undergoes a cyclic proliferation process followed by differentiation under the influence of ovarian steroids and locally produced growth and differentiation factors. Understanding of the molecular mechanisms involved in controlling these processes is of great interest, since imbalances between proliferation- and differentiation-promoting signals can have pathophysiological consequences ranging from infertility to endometrial hyperplasia and tumour formation. The present work reviews aspects of the role played by oncogenes and ovarian steroid receptors in modulating proliferation of endometrial tumour cells. The expression pattern and possible roles of protein kinase C (PKC) subunits are discussed in the context of response-specificity of endometrial tumour cells to tumour-promoting agents such as 12-O-tetradecanoyl-phorbol acetate (TPA) and possible implications for anti-tumour therapy.

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          Author and article information

          Affiliations
          [1 ] IHF, Institute for Hormone and Fertility Research, University of Hamburg, Germany.
          Journal
          Hum. Reprod. Update
          Human reproduction update
          1355-4786
          1355-4786
          : 4
          : 5
          10027605

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