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      A Radiographic Healing Classification for Osteochondritis Dissecans of the Knee Provides Good Interobserver Reliability

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          Abstract

          Background:

          Recent studies have examined radiographic factors associated with healing of osteochondritis dissecans (OCD) lesions of the knee. However, there is still no gold standard in determining the healing status of an OCD lesion.

          Purpose:

          We examined temporally associated patterns of healing to (1) evaluate the practicality of a classification system and (2) elucidate any associations between healing pattern and patient age, sex, lesion location, treatment type, and physeal patency.

          Study Design:

          Cohort study (diagnosis); Level of evidence, 3.

          Methods:

          We retrospectively screened 489 patients from 2006 to 2010 for a total of 41 consecutive knee OCD lesions that met inclusion criteria, including at least 3 consecutive radiographic series (mean patient age, 12.8 years; range, 7.8-17.1 years; mean follow-up, 75.1 weeks). Radiographs were arranged in sequential order for ratings by 2 orthopaedic sports medicine specialists. Healing patterns were rated as boundary resolution, increasing radiodensity of progeny fragment, combined, or not applicable. Repeat ratings were conducted 3 weeks later.

          Results:

          Patients were most commonly adolescent males aged 13 to 17 years, with a medial femoral condyle lesion that was treated operatively. Interobserver reliability of the healing classification was good (intraclass correlation coefficient, 0.67; 95% CI, 0.55-0.79). Boundary and radiodensity healing was observed for all ages, sexes, lesion locations, treatment types, and physeal patency states.

          Conclusion:

          This study evaluated a valuable radiographic paradigm—boundary resolution, increasing radiodensity of progeny fragment, or combined—for assessment of OCD lesion healing. The proposed system of healing classification demonstrated good inter- and intraobserver reliability. Healing patterns were not significantly associated with any particular age, sex, lesion location, treatment type, or physeal patency status. The development of a classification system for knee OCD may eventually improve clinical assessment and management of OCD lesions.

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          Most cited references18

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          Practical Statistics for Medical Research

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            Management of osteochondritis dissecans of the knee: current concepts review.

            Osteochondritis dissecans of the knee is being seen with increased frequency in pediatric and young adult athletes and is thought to be, in part, owing to earlier and increasingly competitive sports participation. Despite much speculation, the cause of both juvenile and adult osteochondritis dissecans remains unclear. Early recognition is essential. Whereas adult osteochondritis dissecans lesions have a greater propensity to instability, juvenile osteochondritis dissecans lesions are typically stable, and those with an intact articular surface have a potential to heal with nonoperative treatment through cessation of repetitive impact loading. The value of adjunctive immobilization, protected weightbearing, and unloader bracing has not been established. Skeletally immature patients with stable lesions that have not healed with nonoperative treatment should have consideration given to arthroscopic drilling to promote healing before the lesion progresses and requires more involved treatment with a less optimistic prognosis. Magnetic resonance imaging may allow early prediction of lesion healing potential. The majority of adult osteochondritis dissecans cases as well as those skeletally immature patients with unstable lesions and secondary loose bodies require fixation and possible bone grafting. Many unstable lesions will heal after stabilization, but long-term prognosis is not clear. Chronic loose fragments can be difficult to fix and have poor healing potential. Results of excision of large lesions from weightbearing zones are poor. Chondral resurfacing techniques have limited long-term data for cases of osteochondritis dissecans in skeletally immature patients.
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              A review of knowledge in osteochondritis dissecans: 123 years of minimal evolution from König to the ROCK study group.

              Osteochondritis dissecans (OCD) was first described to provide an explanation for the nontraumatic development of loose bodies within a joint. Despite many reports on the subject, there remains no clear understanding of the etiology, natural history, or treatment. This review was undertaken to delineate (1) the etiology of OCD; (2) the presentation and locations; (3) the most appropriate imaging modalities; and (4) the most effective treatment strategies. We reviewed the English literature using a database compiled from a Medline search for "osteochondritis dissecans". We identified 1716 publications, 1246 of which were in English. After exclusions, we reviewed 748 articles and of these cited 85. The observations of each study were then synthesized into this report. There appears to be no consensus concerning the etiology of OCD lesions. The presentations and locations are variable, but the knee, ankle, and elbow are most commonly involved. Although plain film assessment is important in OCD, there appears to be a trend toward the use of MRI, but the preferred sequences are in evolution. We found no consensus on the treatment of these lesions, related in part to the lack of agreement of methods for assessing outcomes. Despite more than a century of study, we have made little advancement in our understanding of OCD. A study group has been formed to address this issue and actively seeks to answer these unknown issues regarding OCD.
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                Author and article information

                Journal
                Orthop J Sports Med
                Orthop J Sports Med
                OJS
                spojs
                Orthopaedic Journal of Sports Medicine
                SAGE Publications (Sage CA: Los Angeles, CA )
                2325-9671
                1 December 2017
                December 2017
                : 5
                : 12
                : 2325967117740846
                Affiliations
                []Department of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
                []Sports Medicine and Performance Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
                [§ ]Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
                []Penn Center for Cartilage Repair and Osteochondritis Dissecans Treatment, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
                [5-2325967117740846] Investigation performed at the Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
                Author notes
                [*] [* ]David E. Ramski, MD, Department of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, 3400 Civic Center Boulevard, Wood Building, 2nd Floor, Philadelphia, PA 19104, USA (email: deramski@ 123456gmail.com ).
                Article
                10.1177_2325967117740846
                10.1177/2325967117740846
                5714090
                d66e669e-cf46-40ba-aa71-8c86cb159437
                © The Author(s) 2017

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License ( http://www.creativecommons.org/licenses/by-nc-nd/3.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

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                osteochondritis dissecans,healing classification,reliability,cartilage

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