+1 Recommend
1 collections

      We are delighted to announce our new 2022 CiteScore (issued by Scopus) is 4.6, SNIP 0.868, ranking 22/79 in Category "Biochemistry, Genetics and Molecular Biology (miscellaneous)". Huge thanks to our authors, reviewers and editors for helping to achieve this new milestone for the journal https://www.scopus.com/sourceid/21101107165

      Interested in becoming a BIO Integration published author?

      • Platinum Open Access with no APCs before 2024.
      • Fast peer review/Fast publication online after article acceptance.

      Check out the call for papers on our website: https://bio-integration.org/call-for-papers-bio-integration-2/

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      First experiments with carbon black pigment dispersion acting as a Janus ultrasound contrast agent


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Background: Theranostic ultrasound contrast agents comprise a therapeutic component whose controlled release is triggered by an ultrasound pulse. However, once the therapeutic component has been released from an ultrasound contrast agent microbubble, its intended uptake cannot be monitored, as its acoustically active host has been destroyed. Acoustic Janus particles, whose hydrophobic and hydrophilic properties depend on the external acoustic regime, are of potential use as contrast agents and drug-delivery tracers. The purpose of this study was to evaluate the hypothesis that submicron particles with Janus properties may act as ultrasound contrast agents whose hydrophobicity changes over time.

          Methods: Fifty samples of carbon black were subjected to 5-minute sonication with pulses with a center frequency of 10 MHz and a 1% duty cycle, after which the optical absorption coefficients were measured in n-octanol and water. These coefficients were compared with those of unsonicated samples.

          Results: Our preliminary results show that the difference between the linear absorption coefficients of sonicated and unsonicated samples was Δα = 80 ± 13 m −1 immediately after sonication, indicating that the carbon black particles were less hydrophobic after sonication than prior to it. Forty-eight hours after sonication, the difference in linear optical absorption coefficients had lessened to Δα = 16 ± 9 m −1, indicating that the carbon black particles had become more hydrophobic over time, but not equal to the hydrophobicity situation prior to sonication.

          Conclusion: The experiments confirmed that submicron carbon black particles have acoustic Janus properties.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: not found
          • Book: not found

          CRC Handbook of Chemistry and Physics

            • Record: found
            • Abstract: not found
            • Article: not found

            Octanol‐Water Partition Coefficients of Simple Organic Compounds

              • Record: found
              • Abstract: not found
              • Article: not found

              Hypoxia-specific therapeutic agents delivery nanotheranostics: A sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer


                Author and article information

                BIO Integration
                Compuscript (Ireland )
                August 2023
                08 August 2023
                : 4
                : 2
                : 73-80
                [1] 1School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg 2050, South Africa
                [2] 2BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere 33720, Finland
                Author notes
                *Correspondence to: Craig S. Carlson, BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 3, 33720 Tampere, Finland and School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, 1 Jan Smutslaan, Braamfontein 2050, South Africa, E-mail: craig.carlson@ 123456tuni.fi
                Copyright © 2023 The Authors

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/). See https://bio-integration.org/copyright-and-permissions/

                : 06 March 2023
                : 02 May 2023
                : 11 July 2023
                Self URI (journal-page): https://bio-integration.org/
                Funded by: National Research Foundation of South Africa
                Award ID: 127102
                Funded by: Academy of Finland
                Award ID: 340026
                This study was supported by the National Research Foundation of South Africa, grant Number 127102, and by the Academy of Finland, grant Number 340026. A part of this study was included in a dissertation [33]. The sonography device was kindly supplied by High Tech Medical, Randburg, South Africa.
                Technical Note

                Medicine,Molecular medicine,Radiology & Imaging,Biotechnology,Pharmacology & Pharmaceutical medicine,Microscopy & Imaging
                optical absorption coefficient,hydrophobic contrast agent,transient hydrophilicity,submicron carbon black,Acoustic Janus particles


                Comment on this article