7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Hypertension and circulating mRNA for 11beta-hydroxysteroid dehydrogenase type II.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Circulating DNA and mRNA for 11beta-hydoxysteroid dehydrogenase (HSD) type II were measured in patients with hypertension and in healthy subjects. DNA and RNA levels in hypertensive patients and controls were quantified using real-time RT-PCR. Messenger RNA for 11beta-HSD type II was significantly lower in the hypertensive patients (median: 0.18) (P= 0.032) than in healthy subjects (median: 0.42). Plasma DNA was also significantly lower (P= 0.016) in hypertension. It is suggested that measurement of mRNA for 11beta-HSD type II in hypertension may identify subjects who may be salt-sensitive.

          Related collections

          Author and article information

          Journal
          Ann. N. Y. Acad. Sci.
          Annals of the New York Academy of Sciences
          1749-6632
          0077-8923
          Aug 2008
          : 1137
          Affiliations
          [1 ] Department of Chemical Pathology, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
          Article
          NYAS1137005
          10.1196/annals.1448.005
          18837962
          d6a38b83-e415-461a-8d77-82bd2138b683
          History

          Comments

          Comment on this article