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      The Hemodynamic Response to Digoxin and Proscillaridin during Rest and Exercise in Patients with a Fixed Rate Artificial Pacemaker

      Cardiology

      S. Karger AG

      Digitalis, Proscillaridin, Hemodynamics, Artificial pacemaker

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          Abstract

          Two patients with an artificial pacemaker set at a fixed rate were studied for the hemodynamic response at rest and during exercise before and after the administration of proscillaridin, a glycoside from Scilla maritima. Five such patients were studied in the same way before and after the administration of digoxin. Both proscillaridin and digoxin produced a benificial effect on the circulation during exercise in decompensated patients; the cardiac output and stroke volume tended to increase and the pulmonary capillary venous and pulmonary artery pressure decreased after the administration of proscillaridin and digoxin, as did the atrial rate.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1972
          1972
          29 October 2008
          : 57
          : 3
          : 126-134
          Affiliations
          Heart Laboratory, General Hospital, Malmö
          Article
          169511 Cardiology 1972;57:126–134
          10.1159/000169511
          5064964
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 9
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