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      Pediatric acute-onset neuropsychiatric syndrome.

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          Abstract

          Whether some instances of obsessive-compulsive disorder are secondary to infectious and/or autoimmune processes is still under scientific debate. The nosology has undergone an iterative process of criteria and acronyms from PITANDS to PANDAS to PANS (or CANS for neurology). This review focuses on the clinical presentation, assessment, proposed pathophysiology, and treatment of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS), and the newest iteration, pediatric acute-onset neuropsychiatric syndrome (PANS). Children who have these symptoms, which have become known as PANS, have been described by their parents as "changed children."

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          Author and article information

          Journal
          Psychiatr. Clin. North Am.
          The Psychiatric clinics of North America
          Elsevier BV
          1558-3147
          0193-953X
          Sep 2014
          : 37
          : 3
          Affiliations
          [1 ] Rothman Center for Pediatric Neuropsychiatry, USF Pediatrics, 880 6th Street South, Suite 460, Box 7523, St Petersburg, FL 33701, USA. Electronic address: tmurphy@health.usf.edu.
          [2 ] Rothman Center for Pediatric Neuropsychiatry, USF Pediatrics, 880 6th Street South, Suite 460, Box 7523, St Petersburg, FL 33701, USA.
          [3 ] Child Study Center, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT 06520, USA.
          Article
          S0193-953X(14)00055-0
          10.1016/j.psc.2014.06.001
          25150567
          d6bcb6b0-38ab-4786-a5fe-2ba5e82d2de1
          History

          Streptococcal infections,Pediatric autoimmune neuropsychiatric disorder,PANDAS

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