Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Richa Saxena and colleagues report genome-wide association analyses of sleep disturbance traits in the UK Biobank cohort. They discover loci associated with insomnia symptoms and excessive daytime sleepiness and identify genetic correlations with several neuropsychiatric and metabolic traits.

Related collections

Most cited references 59

Record: found
Abstract: found
Article: not found

Slow-wave sleep and the risk of type 2 diabetes in humans.

Esra Tasali, Rachel Leproult, David A Ehrmann … (2008)

There is convincing evidence that, in humans, discrete sleep stages are important for daytime brain function, but whether any particular sleep stage has functional significance for the rest of the body is not known. Deep non-rapid eye movement (NREM) sleep, also known as slow-wave sleep (SWS), is thought to be the most "restorative" sleep stage, but beneficial effects of SWS for physical well being have not been demonstrated. The initiation of SWS coincides with hormonal changes that affect glucose regulation, suggesting that SWS may be important for normal glucose tolerance. If this were so, selective suppression of SWS should adversely affect glucose homeostasis and increase the risk of type 2 diabetes. Here we show that, in young healthy adults, all-night selective suppression of SWS, without any change in total sleep time, results in marked decreases in insulin sensitivity without adequate compensatory increase in insulin release, leading to reduced glucose tolerance and increased diabetes risk. SWS suppression reduced delta spectral power, the dominant EEG frequency range in SWS, and left other EEG frequency bands unchanged. Importantly, the magnitude of the decrease in insulin sensitivity was strongly correlated with the magnitude of the reduction in SWS. These findings demonstrate a clear role for SWS in the maintenance of normal glucose homeostasis. Furthermore, our data suggest that reduced sleep quality with low levels of SWS, as occurs in aging and in many obese individuals, may contribute to increase the risk of type 2 diabetes.

0 comments Cited 231 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

UK biobank data: come and get it.

Naomi Allen, Cathie Sudlow, Tim Peakman … (2014)

0 comments Cited 172 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Sleep problems: an emerging global epidemic? Findings from the INDEPTH WHO-SAGE study among more than 40,000 older adults from 8 countries across Africa and Asia.

Saverio Stranges, William Tigbe, Francesc Xavier Gómez-Olivé … (2012)

To estimate the prevalence of sleep problems and the effect of potential correlates in low-income settings from Africa and Asia, where the evidence is lacking. Cross-sectional. Community-wide samples from 8 countries across Africa and Asia participating in the INDEPTH WHO-SAGE multicenter collaboration during 2006-2007. The participating sites included rural populations in Ghana, Tanzania, South Africa, India, Bangladesh, Vietnam, and Indonesia, and an urban area in Kenya. There were 24,434 women and 19,501 men age 50 yr and older. N/A. Two measures of sleep quality, over the past 30 days, were assessed alongside a number of sociodemographic variables, measures of quality of life, and comorbidities. Overall, 16.6% of participants reported severe/extreme nocturnal sleep problems, with a striking variation across the 8 populations, ranging from 3.9% (Purworejo, Indonesia and Nairobi, Kenya) to more than 40.0% (Matlab, Bangladesh). There was a consistent pattern of higher prevalence of sleep problems in women and older age groups. In bivariate analyses, lower education, not living in partnership, and poorer self-rated quality of life were consistently associated with higher prevalence of sleep problems (P < 0.001). In multivariate logistic regression analyses, limited physical functionality or greater disability and feelings of depression and anxiety were consistently strong, independent correlates of sleep problems, in both women and men, across the 8 sites (P < 0.001). A large number of older adults in low-income settings are currently experiencing sleep problems, which emphasizes the global dimension of this emerging public health issue. This study corroborates the multifaceted nature of sleep problems, which are strongly linked to poorer general well-being and quality of life, and psychiatric comorbidities.

0 comments Cited 164 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Nature Genetics

Abbreviated Title: Nat Genet

Publisher: Springer Nature

ISSN (Print): 1061-4036

ISSN (Electronic): 1546-1718

Publication date Created: December 19 2016

Publication date (Print): December 19 2016

Volume:

Issue:

Article

DOI: 10.1038/ng.3749

PMC ID: 5491693

PubMed ID: 27992416

SO-VID: d6bdf335-9f7c-42f7-bd9c-c8642debe38f

History

Data availability:

Comments

Comment on this article

scite_

Cited by 124

See all cited by

Most referenced authors 4,819

See all reference authors

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Read this article at

Abstract

Related collections

Genome Integrity

Most cited references 59

Slow-wave sleep and the risk of type 2 diabetes in humans.

UK biobank data: come and get it.

Sleep problems: an emerging global epidemic? Findings from the INDEPTH WHO-SAGE study among more than 40,000 older adults from 8 countries across Africa and Asia.

Author and article information

Journal

Article

History

Comments

Comment on this article

Similar content 128

Cited by 124

Most referenced authors 4,819