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      Ethylenediamine tetraacetate: Its Release from Hydrophilic Gel Contact Lenses, Intraocular Penetration and Effect on Calcium in the Cornea after Lime Burns

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          In spite of a standard lime burn technique, the injured rabbit eyes revealed a great variety of corneal damage with totally or partially denuded epithelium and stromal opacities of varying intensity. Irrigation of the eye with water removed more than half of the calcium from the cornea. A further significant decrease of the calcium level was achieved by the action of hydrophilic gel contact lens presoaked with a 1.85% ethylenediamine tetra acetate (EDTA) solution. The lime-burned cornea does not prevent intraocular penetration of EDTA from contact lens fitted on the injured eye. A delay of 1 or 2 h in application of EDTA contact lens after the lime burn and water irrigation of the eye seems to enhance permeation of the chelating agent into the cornea

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          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 8
          : 3
          : 161-168
          Institute of Experimental Medicine (Director: Doc. Dr. V. Kusák), Czechoslovak Academy of Sciences, and Department of Ophthalmology (Director: Doc. Dr. J. Votočková), Charles University, Prague
          264812 Ophthalmic Res 1976;8:161–168
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 8


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