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      Ethylenediamine tetraacetate: Its Release from Hydrophilic Gel Contact Lenses, Intraocular Penetration and Effect on Calcium in the Cornea after Lime Burns

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          Abstract

          In spite of a standard lime burn technique, the injured rabbit eyes revealed a great variety of corneal damage with totally or partially denuded epithelium and stromal opacities of varying intensity. Irrigation of the eye with water removed more than half of the calcium from the cornea. A further significant decrease of the calcium level was achieved by the action of hydrophilic gel contact lens presoaked with a 1.85% ethylenediamine tetra acetate (EDTA) solution. The lime-burned cornea does not prevent intraocular penetration of EDTA from contact lens fitted on the injured eye. A delay of 1 or 2 h in application of EDTA contact lens after the lime burn and water irrigation of the eye seems to enhance permeation of the chelating agent into the cornea

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1976
          1976
          03 December 2009
          : 8
          : 3
          : 161-168
          Affiliations
          Institute of Experimental Medicine (Director: Doc. Dr. V. Kusák), Czechoslovak Academy of Sciences, and Department of Ophthalmology (Director: Doc. Dr. J. Votočková), Charles University, Prague
          Article
          264812 Ophthalmic Res 1976;8:161–168
          10.1159/000264812
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 8
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