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      Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans?

      Cancer research
      Animals, Antineoplastic Agents, pharmacology, therapeutic use, Humans, Mice, Neoplasm Metastasis, prevention & control, TNF-Related Apoptosis-Inducing Ligand, physiology

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          Abstract

          Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy, as it can induce apoptosis specifically in tumor cells but not in normal cells. Although earlier mouse tumor studies revealed a strong tissue dependency of TRAIL and its death receptor in suppressing primary tumorigenesis or experimental metastases, we recently found that TRAIL-R inhibits lymph node metastases without affecting primary tumor formation in a mouse model of multistage skin tumorigenesis. This finding uncouples the role of TRAIL in primary tumorigenesis from metastasis formation, likely by sensitization of previously TRAIL-resistant tumor cells upon detachment, an early step required for metastasis formation. Therefore, TRAIL-R is a novel metastasis suppressor, suggesting that TRAIL-related tumor therapy might be most effective in primary tumors and early metastatic cancers, before selection for TRAIL resistance occurs.

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          Author and article information

          Journal
          18676822
          2665198
          10.1158/0008-5472.CAN-08-0078

          Chemistry
          Animals,Antineoplastic Agents,pharmacology,therapeutic use,Humans,Mice,Neoplasm Metastasis,prevention & control,TNF-Related Apoptosis-Inducing Ligand,physiology

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