FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Objective To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.

Design Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.

Data sources Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.

Eligibility criteria for study selection Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.

Results We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.

Conclusions We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.

Systematic review registration PROSPERO CRD42015015969.

Related collections

Author and article information

Contributors

Katherine M Livingstone: Role: postdoctoral research fellow

Carlos Celis-Morales: Role: research associate

George D Papandonatos: Role: associate professor

Bahar Erar: Role: doctoral student

Jose C Florez: Role: chief of the Diabetes Unit, member of the Center for Human Genetic Research, and associate professor

Kathleen A Jablonski: Role: associate research professor

Cristina Razquin: Role: research associate

Amelia Marti: Role: professor of human physiology

Yoriko Heianza: Role: postdoctoral fellow

Tao Huang: Role: postdoctoral fellow

Frank M Sacks: Role: professor

Mathilde Svendstrup: Role: research fellow

Xuemei Sui: Role: assistant professor graduate director

Timothy S Church: Role: professor

Tiina Jääskeläinen: Role: postdoctoral fellow

Jaana Lindström: Role: adjunct professor

Jaakko Tuomilehto: Role: professor

Matti Uusitupa: Role: professor emeritus

Tuomo Rankinen: Role: associate professor human genomics

Wim H M Saris: Role: professor of human nutrition

Torben Hansen: Role: professor

Oluf Pedersen: Role: scientific director

Arne Astrup: Role: head of department, senior consultant, and professor

Thorkild I A Sørensen: Role: professor of metabolic epidemiology, director, chief physician in clinical epidemiology, and professor of clinical epidemiology

Lu Qi: Role: professor

George A Bray: Role: professor

Miguel A Martinez-Gonzalez: Role: professor of preventive medicine and public health

J Alfredo Martinez: Role: professor of human nutrition and scientific director

Paul W Franks: Role: professor

Jeanne M McCaffery: Role: associate professor of psychiatry and human behaviour

Jose Lara: Role: senior lecturer

John C Mathers: Role: professor of human nutrition

Journal

Journal ID (nlm-ta): BMJ

Journal ID (iso-abbrev): BMJ

Journal ID (publisher-id): bmj

Title: The BMJ

Publisher: BMJ Publishing Group Ltd.

ISSN (Print): 0959-8138

ISSN (Electronic): 1756-1833

Publication date Collection: 2016

Publication date (Electronic): 19 September 2016

Volume: 354

Electronic Location Identifier: i4707

Affiliations

[1 ]Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK

[2 ]Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Victoria, Australia

[3 ]BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK

[4 ]Department of Biostatistics, Brown University School of Public Health, Providence, RI, USA

[5 ]Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA

[6 ]Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

[7 ]George Washington University Department of Epidemiology and Biostatistics The Biostatistics Center, Rockville, MD, USA

[8 ]Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

[9 ]CIBER Fisiopatologia de la Obesidad y Nutricion and PREDIMED Network from Instituto de Salud Carlos III Spanish Government, Spain

[10 ]Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain

[11 ]Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA

[12 ]Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore

[13 ]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

[14 ]Novo Nordisk Foundation Centre for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

[15 ]Danish Diabetes Academy, Odense, Denmark

[16 ]Department of Exercise Science, University of South Carolina, Columbia, SC, USA

[17 ]Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA

[18 ]Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

[19 ]Department of Medical and Clinical Genetics, University of Helsinki, Finland

[20 ]Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

[21 ]Dasman Diabetes Institute, Dasman, Kuwait City, Kuwait

[22 ]Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

[23 ]Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA

[24 ]Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, Netherlands

[25 ]Department of Nutrition, Exercise and Sports, Copenhagen University, Rolighedsvej 30, Frederiksberg C, Denmark

[26 ]Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Denmark

[27 ]Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain

[28 ]Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden

[29 ]The Miriam Hospital and the Alpert School of Medicine, Brown University, Providence, USA

[30 ]Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK

Author notes

Correspondence to: J C Mathers john.mathers@ 123456newcastle.ac.uk

Article

Publisher ID: livk032914

DOI: 10.1136/bmj.i4707

PMC ID: 6168036

PubMed ID: 27650503

SO-VID: d6d8d2f4-c04c-4495-9d42-2effc800b737

License:

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/.

History

Date accepted : 17 August 2016

Comments

Comment on this article

scite_

Cited by 48

See all cited by

- Version 1