Blog
About

  • Record: found
  • Abstract: not found
  • Article: not found

Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis : New RAS inhibitor poricoic acid against renal fibrosis

Read this article at

ScienceOpenPublisher
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 58

      • Record: found
      • Abstract: not found
      • Article: not found

      Animal research: reporting in vivo experiments: the ARRIVE guidelines.

        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.

        Melanoma treatment is being revolutionized by the development of effective immunotherapeutic approaches. These strategies include blockade of immune-inhibitory receptors on activated T cells; for example, using monoclonal antibodies against CTLA-4, PD-1, and PD-L1 (refs 3-5). However, only a subset of patients responds to these treatments, and data suggest that therapeutic benefit is preferentially achieved in patients with a pre-existing T-cell response against their tumour, as evidenced by a baseline CD8(+) T-cell infiltration within the tumour microenvironment. Understanding the molecular mechanisms that underlie the presence or absence of a spontaneous anti-tumour T-cell response in subsets of cases, therefore, should enable the development of therapeutic solutions for patients lacking a T-cell infiltrate. Here we identify a melanoma-cell-intrinsic oncogenic pathway that contributes to a lack of T-cell infiltration in melanoma. Molecular analysis of human metastatic melanoma samples revealed a correlation between activation of the WNT/β-catenin signalling pathway and absence of a T-cell gene expression signature. Using autochthonous mouse melanoma models we identified the mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy. Specific oncogenic signals, therefore, can mediate cancer immune evasion and resistance to immunotherapies, pointing to new candidate targets for immune potentiation.
          Bookmark
          • Record: found
          • Abstract: not found
          • Article: not found

          Experimental design and analysis and their reporting: new guidance for publication in BJP.

            Bookmark

            Author and article information

            Affiliations
            [1 ]Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science; Northwest University; Xi'an Shaanxi 710069 China
            [2 ]School of Pharmacy; Zhejiang Chinese Medical University; Hangzhou Zhejiang 310053 China
            [3 ]Division of Nephrology and Hypertension, School of Medicine; University of California Irvine; Irvine CA 92897 USA
            [4 ]Department of Internal Medicine; University of New Mexico, Comprehensive Cancer Center; Albuquerque NM 87131 USA
            Journal
            British Journal of Pharmacology
            British Journal of Pharmacology
            Wiley
            00071188
            July 2018
            July 2018
            May 22 2018
            : 175
            : 13
            : 2689-2708
            10.1111/bph.14333
            © 2018

            http://doi.wiley.com/10.1002/tdm_license_1.1

            http://onlinelibrary.wiley.com/termsAndConditions#vor

            Comments

            Comment on this article