Correction to: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Correction to: Chin Med (2019) 14:37 10.1186/s13020-019-0254-9 In the original publication of this article [1], another affiliation (Affiliation 3: University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China.) for the author Ziqiong Guo is missing due to the carelessness during the author proof. In addition, in Affiliation 2 “Chinese Academy of Science” should be changed to “Chinese Academy of Sciences”. The full author affiliation for Ziqiong Guo is Ziqiong Guo2,3: 2Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China. 3University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China. The authors sincerely apologize for the inconvenience caused to the readers.

Related collections

Most cited references 1

Record: found
Abstract: found
Article: found

Is Open Access

Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Ming Zhong, Xiaoting Tian, Shuoji Chen … (2019)

Background Modern pharmacological studies have demonstrated that Baihe–Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely to be understood and accepted than evidence-based active natural compounds. Methods In this study, an effective method for the identification of antidepressant components was demonstrated and applied to BZD. The first step was to evaluate the efficacy of BZD by the forced swimming test (FST) and the tail suspension test (TST), followed by successive quantitative analyses of the absorbed constituents at different stages, such as before hepatic disposition, liver distribution, after hepatic disposition and brain distribution after the oral administration of BZD. Finally, the compounds detected in the brain were confirmed by activity testing. Results Our investigation observed that timosaponin BII and timosaponin BIII were accurately determined in the brain after oral administration of BZD, and they were further confirmed to reduce the immobility time in the FST and TST. As described above, timosaponin BII and timosaponin BIII were used to scientifically and reasonably explain the effective chemical basis of the effect of BZD on depression. Conclusions This research affords an effective method to discover lead molecules for antidepressants from traditional Chinese medicine.

0 comments Cited 7 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Fang Liu: lf86614@126.com

Chenggang Huang:

ORCID: http://orcid.org/0000-0001-9209-7484

cghsimm@126.com

Journal

Journal ID (nlm-ta): Chin Med

Journal ID (iso-abbrev): Chin Med

Title: Chinese Medicine

Publisher: BioMed Central (London )

ISSN (Electronic): 1749-8546

Publication date (Electronic): 2 April 2020

Publication date PMC-release: 2 April 2020

Publication date Collection: 2020

Volume: 15

Electronic Location Identifier: 32

Affiliations

[1 ]GRID grid.449428.7, ISNI 0000 0004 1797 7280, College of Pharmacy, , Jining Medical University, ; Rizhao, 276826 People’s Republic of China

[2 ]GRID grid.9227.e, ISNI 0000000119573309, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, , Chinese Academy of Sciences, ; Shanghai, 201203 People’s Republic of China

[3 ]GRID grid.410726.6, ISNI 0000 0004 1797 8419, University of Chinese Academy of Sciences, ; Beijing, 100049 People’s Republic of China

Author information

Chenggang Huang http://orcid.org/0000-0001-9209-7484

Article

Publisher ID: 312

DOI: 10.1186/s13020-020-00312-2

PMC ID: 7115082

SO-VID: d6e53ea6-09f5-443a-bcb2-0941f354602d

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Custom metadata

ScienceOpen disciplines: Complementary & Alternative medicine

Data availability:

ScienceOpen disciplines: Complementary & Alternative medicine

Comments

Comment on this article

scite_

Most referenced authors 13

See all reference authors