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In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost-Effective, Metal-Assisted Chemical Etching.

Author(s): Nancy Wareing, Kyle Szymanski, Giridhar R Akkaraju, Armando Loni, Leigh T Canham, Roberto Gonzalez-Rodriguez, Jeffery L Coffer

Publication date: 2017

Journal: Small (Weinheim an Der Bergstrasse, Germany)

Publisher: Wiley

Keywords: nanomedicine, stain etching, porous silicon, surface modification, gene delivery

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Abstract

The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.

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PubMed ID:: 28084695

DOI:: 10.1002/smll.201602739

Keywords: nanomedicine,stain etching,porous silicon,surface modification,gene delivery

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Keywords: nanomedicine, stain etching, porous silicon, surface modification, gene delivery

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