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      Cataracts in the Aging Rat Lens

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          Abstract

          Two types of cortical cataract were observed in senile Wistar rats: posterior subcapsular (PSC) and supranuclear (SNC). The beginning of PSC was denoted clinically by vacuole accumulation in the posterior suture. The appearance of vacuoles, granules and cloudiness spread laterally in all directions, maintaining a primarily superficial cortical distribution. Microscopic comparison of rat and human forms showed the opacity to represent subcapsular accumulations of fluid and cytoplasmic residues, generated by the swelling and disintegration of basal extremities of fiber cells. The clinical onset of murine SNC was usually represented by small vacuole accumulation in the anterior cortical suture system. Later, lamellar separations formed in the outer cortex, followed by the development of water clefts in the deeper cortex. Microscopically, advanced forms showed extensive swelling and coalescence of cortical fibers, associated with Morgagnian globules and myelin figures.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1977
          1977
          03 December 2009
          : 9
          : 5
          : 329-342
          Affiliations
          Department of Anatomy, Colorado State University, Fort Collins, Colo.
          Article
          264903 Ophthalmic Res 1977;9:329–342
          10.1159/000264903
          © 1977 S. Karger AG, Basel

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          Pages: 14
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