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      Myelination and support of axonal integrity by glia.

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      Nature
      Springer Science and Business Media LLC

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          Abstract

          The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon-glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Nov 11 2010
          : 468
          : 7321
          Affiliations
          [1 ] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany. nave@em.mpg.de
          Article
          nature09614
          10.1038/nature09614
          21068833
          d7083a44-5aaa-42a2-8344-72b002056de4
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