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      [Inflammation as molecular target in chondrosarcoma].

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      Der Pathologe
      Springer Nature America, Inc

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          Abstract

          Inflammation is a hallmark in the development and progression of malignant tumors. In chondrosarcoma the inflammatory changes are relatively discrete; however, tumor-associated macrophages (TAM) may exert tumor-promoting effects. Interleukin (IL)-1 is an inflammatory cytokine which is produced by TAMs and which leads to the expression of NF-κB-regulated genes in chondrosarcoma cells, such as vascular endothelial growth factor A (VEGF-A). Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.

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          Author and article information

          Journal
          Pathologe
          Der Pathologe
          Springer Nature America, Inc
          1432-1963
          0172-8113
          Nov 2014
          : 35 Suppl 2
          Affiliations
          [1 ] Institut für Pathologie, Otto-von-Guericke-Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland, kalinski@med.ovgu.de.
          Article
          10.1007/s00292-014-1968-1
          25394974
          d71bf49b-8fb6-4154-9d4d-389b85b264dd
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