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      Expression and Distribution of Kallikrein-Binding Protein mRNA in Rat Ocular Tissues

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          Abstract

          Kallikrein-binding protein (KBP) has recently been characterized as an endogenous inhibitor of kallikrein, and it is considered to be involved in several pathophysiological processes, such as hypertension. In the eye, its source has not been determined. We have investigated KBP mRNA expression in the ocular tissues of 5 Wistar-Kyoto rats using the technique of reverse transcription with polymerase chain reaction. Five cornea, sclera, iris, ciliary body and choroid samples were negative for KBP. Four retina samples were positive. KBP mRNA was more significantly expressed in the retina than in the other ocular tissues (p = 0.0238<0.05). Our present study demonstrates that KBP is synthesized in the rat retina, suggesting that KBP alteration may be involved in the retinal circulation.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1998
          October 1998
          12 August 1998
          : 212
          : 5
          : 334-336
          Affiliations
          Department of Ophthalmology, Yamagata University School of Medicine, Yamagata, Japan
          Article
          27319 Ophthalmologica 1998;212:334–336
          10.1159/000027319
          9693292
          © 1998 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 3
          Categories
          Original Paper · Travail original · Originalarbeit

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