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      Number of children and the prevalence of later-life major depression and insomnia in women and men: findings from a cross-sectional study of 0.5 million Chinese adults

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          Abstract

          Background

          Pregnancy and parenthood have been associated with physical and mental health. Previous literature concerning the impacts of parity on mental health was inconsistent and lack epidemiolocal evidence. China, with growing mental health problems and changing fertility patterns, faces unique challenges. This study aims to examine the relationship between parity and the prevalence of major depression and insomnia among men and women in the Chinese population.

          Methods

          Baseline data from a Chinese population-based study of 512,891 adults (59.01% women) from 10 areas, aged 30–79 were analyzed. Number of children was based on self-report by the participants. Major depression (MD) was assessed using the Composite International Diagnostic Inventory. Insomnia symptoms were accessed by a questionnaire comparable to that used in the Diagnostic and Statistical Manual of Mental Disorders. Logistic regression was used to assess the relationship between MD/Insomnia and number of children, after stratifications and adjustments.

          Results

          For women, each additional child was associated with a 9% decreased odds of MD (OR: 0.91, 95%CI: 0.88–0.96), with the associations significant for those who lived in urban areas (OR: 0.76, 95%CI: 0.70–0.83), or had a lower education (OR: 0.90, 95%CI: 0.85–0.94), or had lower household income (OR: 0.89, 95%CI: 0.85–0.94), or had ever used alcohol (OR: 0.89, 95%CI: 0.84–0.93). The association between per additional children and MD was not significant in men (OR: 1.02, 95%CI: 0.97–1.07), but a decreased odd of MD with per additional child was found in men who lived in urban areas (OR: 0.81, 95%CI: 0.71–0.96). For women, each additional child was associated with a 4% decreased odds of insomnia (OR: 0.96, 95%CI: 0.95–0.96). Each additional child was also associated with a 2% decreased odds of insomnia in men (OR: 0.98, 95%CI: 0.97–1.00).

          Conclusions

          MD and insomnia were inversely associated with number of children in women while the association was not overall significant in men. The association was mediated by socioeconomic and lifestyle factors. Future mental health public health programs should address parity and sex differences when designing interventions.

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          Most cited references33

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          Urbanisation and health in China

          Summary China has seen the largest human migration in history, and the country's rapid urbanisation has important consequences for public health. A provincial analysis of its urbanisation trends shows shifting and accelerating rural-to-urban migration across the country and accompanying rapid increases in city size and population. The growing disease burden in urban areas attributable to nutrition and lifestyle choices is a major public health challenge, as are troubling disparities in health-care access, vaccination coverage, and accidents and injuries in China's rural-to-urban migrant population. Urban environmental quality, including air and water pollution, contributes to disease both in urban and in rural areas, and traffic-related accidents pose a major public health threat as the country becomes increasingly motorised. To address the health challenges and maximise the benefits that accompany this rapid urbanisation, innovative health policies focused on the needs of migrants and research that could close knowledge gaps on urban population exposures are needed.
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            The neuroprotective actions of oestradiol and oestrogen receptors.

            Hormones regulate homeostasis by communicating through the bloodstream to the body's organs, including the brain. As homeostatic regulators of brain function, some hormones exert neuroprotective actions. This is the case for the ovarian hormone 17β-oestradiol, which signals through oestrogen receptors (ERs) that are widely distributed in the male and female brain. Recent discoveries have shown that oestradiol is not only a reproductive hormone but also a brain-derived neuroprotective factor in males and females and that ERs coordinate multiple signalling mechanisms that protect the brain from neurodegenerative diseases, affective disorders and cognitive decline.
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              Mental health in China: challenges and progress.

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                Author and article information

                Contributors
                whybest@pku.edu.cn
                mchen16@live.unc.edu
                xtong.katrina@gmail.com
                tangkun@post.harvard.edu
                Journal
                BMC Psychiatry
                BMC Psychiatry
                BMC Psychiatry
                BioMed Central (London )
                1471-244X
                29 May 2020
                29 May 2020
                2020
                : 20
                : 267
                Affiliations
                [1 ]GRID grid.12527.33, ISNI 0000 0001 0662 3178, Research Center for Public Health, School of Medicine, , Tsinghua University, ; Haidian District, Beijing, China
                [2 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, School of Health Humanities, , Peking University Health Science Center, ; No. 38 Xueyuan Road, Haidian District, Beijing, China
                [3 ]GRID grid.10698.36, ISNI 0000000122483208, Department of Sociology, , University of North Carolina at Chapel Hill, ; 103 S Bldg Cb 9100, Chapel Hill, United States
                [4 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, Department of Global Health, , Peking University Health Science Center, ; No. 38 Xueyuan Road, Beijing, 100191 China
                Author information
                http://orcid.org/0000-0002-5444-186X
                Article
                2681
                10.1186/s12888-020-02681-2
                7260797
                32471396
                d756d0d6-dfe5-42b1-9a67-3aef362900ed
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 8 November 2019
                : 18 May 2020
                Funding
                Funded by: the National Key Research and Development Program of China
                Award ID: 2016YFC0900500, 2016YFC0900501, 2016YFC0900504,
                Funded by: Kadoorie Charitable Foundation
                Award ID: 088158/Z/09/Z, 104085/Z/14/Z, 104085/Z/14/Z
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2020

                Clinical Psychology & Psychiatry
                major depression,insomnia,parity,sex differences,china
                Clinical Psychology & Psychiatry
                major depression, insomnia, parity, sex differences, china

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