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      Organoids as an in vitro model of human development and disease.

      1 , 1 , 1 , 2 , 3
      Nature cell biology

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          Abstract

          The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

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          Author and article information

          Journal
          Nat. Cell Biol.
          Nature cell biology
          1476-4679
          1465-7392
          Mar 2016
          : 18
          : 3
          Affiliations
          [1 ] A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
          [2 ] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
          [3 ] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.
          Article
          ncb3312
          10.1038/ncb3312
          26911908
          d758d73e-9b00-4d14-a535-c7fc0fa617c1
          History

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