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      Susceptibility or resistance of praziquantel in human schistosomiasis: a review.

      1 , ,
      Parasitology research
      Springer Science and Business Media LLC

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          Abstract

          Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to become the only drug of choice for treatment of human schistosomiases, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost. Praziquantel-based chemotherapy has been involved in the global control strategy of the disease and led to the control strategy shifting from disease control to morbidity control, which has greatly reduced the prevalence and intensity of infections. Given that the drug has been widely used for morbidity control in endemic areas for more than three decades, the emergence of resistance of Schistosoma to praziquantel under drug selection pressure has been paid much attention. It is possible to induce resistance of Schistosoma mansoni and Schistosoma japonicum to praziquantel in mice under laboratorial conditions, and a reduced susceptibility to praziquantel in the field isolates of S. mansoni has been found in many foci. In addition, there are several schistosomiasis cases caused by Schistosoma haematobium infections in which repeated standard treatment fails to clear the infection. However, in the absence of exact mechanisms of action of praziquantel, the mechanisms of drug resistance in schistosomes remain unclear. The present review mainly demonstrates the evidence of drug resistance in the laboratory and field and the mechanism of praziquantel resistance and proposes some strategies for control of praziquantel resistance in schistosomes.

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          Author and article information

          Journal
          Parasitol Res
          Parasitology research
          Springer Science and Business Media LLC
          1432-1955
          0932-0113
          Nov 2012
          : 111
          : 5
          Affiliations
          [1 ] Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province 214064, People's Republic of China. wangweijipd@yahoo.com.cn
          Article
          10.1007/s00436-012-3151-z
          23052781
          d77f0326-0df3-48ac-a2a0-650662529c7a
          History

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