Effect of Aluminum on Porphyrin Metabolism in Hemodialyzed Patients

Abstract

In patients with renal failure and on chronic hemodialysis, serum aluminum, serum delta-aminolevulinic acid, serum porphobilinogen and erythrocyte zinc protoporphyrin (ZPP) are significantly elevated, whereas erythrocyte delta-aminolevulinic acid dehydratase activity (ALAD, values in percent) is significantly reduced. The last two parameters (ZPP and ALAD) are statistically related to serum aluminum concentration (Al-S), but only the correlation between Al-S and ALAD remains statistically significant after standardization for the degree of renal insufficiency (expressed in terms of urea level). This study does not support the hypothesis that the retention of aluminum is responsible for the increase of ZPP in uremic patients on dialysis. The disturbances of porphyrin metabolism found in patients with renal failure and on chronic dialysis are not similar to those observed in porphyria cutanea tarda.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 05 December 2008

Volume: 46

Issue: 4

Pages: 360-363

Affiliations

^aUnité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, ^bService de Biochimie Médicale, Cliniques Universitaires Saint-Luc, et ^cDépartement de Néphrologie-Dialyse, Hôpital Universitaire Brugmann, Bruxelles, Belgique

Article

Publisher ID: 184390 Other ID: Nephron 1987;46:360–363

DOI: 10.1159/000184390

PubMed ID: 3658064

Copyright statement: © 1987 S. Karger AG, Basel

License:

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Page count

Pages: 4

Product

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Categories

Subject: Original Paper