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      Effect of contrasted levels of habitual physical activity on metabolic flexibility.

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          Abstract

          The factors regulating the body's ability to switch from fat to carbohydrate oxidation in response to fuel availability changes, or metabolic flexibility (MF), are currently intensively investigated in the context of metabolic diseases. Although numerous metabolic diseases are associated with sedentary behaviors and metabolic inflexibility, the effect of habitual physical activity level (PAL) on MF regulation is surprisingly poorly known. We investigated how PAL affects MF in cross-sectional and interventional studies. MF was assessed in 44 subjects: normal-weight and overweight sedentary men submitted to 2 mo of exercise at current recommendations, normal-weight active men submitted to 1 mo of reduced PAL and normal-weight women submitted to 1 mo of bed rest, with or without exercise. MF was evaluated, before and after interventions, following two standard meals as the relationship between individual mathematical variances in insulin and nonprotein respiratory quotient (NPRQ) daily kinetics. Daily NPRQ and insulin variances differed according to habitual PAL (P = 0.002 and P = 0.009, respectively); active subjects had higher variances in NPRQ for lower variances in insulin than sedentary subjects, indicating a better MF. Detraining increased insulin variance (P = 0.009) and decreased NPRQ variance (P = 0.003), while training tended to have opposite effects. Insulin and NPRQ variances were negatively related along the PAL continuum (R(2) = 0.70, P < 0.001). Variance in NPRQ was also positively related to PAL (R(2) = 0.52, P < 0.001). By assessing MF with mathematical surrogates in conditions of daily pattern in meal's intake, we showed that habitual PAL is associated with MF status, and that MF is modulated by changes in PAL.

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          Author and article information

          Journal
          J. Appl. Physiol.
          Journal of applied physiology (Bethesda, Md. : 1985)
          1522-1601
          0161-7567
          Feb 2013
          : 114
          : 3
          Affiliations
          [1 ] Institut Pluridisciplinaire Hubert Curien, Département d'Ecologie, Physiologie et Ethologie, UMR 7178 Centre National de la Recherche Scientifique, Strasbourg, France.
          Article
          japplphysiol.00458.2012
          10.1152/japplphysiol.00458.2012
          23239872
          d785ea0c-f76b-4b5c-a578-9b93f66ea983
          History

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