Influences of infection types and treatment methods on clearance time of Plasmodium falciparum LDH antigen

Abstract

Objective To compare the effects of different types of malaria infection and treatment methods on Plasmodium falciparum LDH antigen clearance in patients.

Methods According to the clinical data, 4 groups of patients were selected from the confirmed malaria patients in the MONUSCO Peacekeeping Level II hospital and level I Hospital according to the difference of their malaria infection type and treatment process, each group including 10 patients. Peripheral blood samples were collected from malaria patients 3 days, 7 days, 14 days and 21 days after the end of the course. LDH-based rapid detection kit was used to detect LDH antigen residues in patients.

Results There was no significant difference in the time of LDH to become negative between Plasmodium falciparum single infection group and mixed infection group ( P>0.05). There were significant differences in the time of LDH to become negative between two artesunate injection groups and oral Artesunate/Amodiaquine treatment group ( P<0.05). There was no significant difference in the time of LDH to become negative between two artesunate injection groups ( P>0.05).

Conclusion Different types of malaria infection had no effect on the duration of Plasmodium falciparum LDH in patients. Artesunate injection therapy can clean up the Plasmodium falciparum LDH antigen more quickly than Artesunate/Amodiaquine oral therapy.

Abstract

摘要： 目的 比较不同疟原虫感染型别及治疗方法对患者体内恶性疟原虫LDH抗原清除时间的影响。 方法依据临床资料，在联合国刚果(金)稳定特派团维和二级医院及一级医院确诊的疟疾患者中按照其疟原虫感染型别及治疗过程的差异选取患者，组成4组，每组纳人10例。在疟疾病人疗程结束后的第3天、第7天、第14天、第21天分别采集外周血，使用基于LDH的疟原虫快速检测试剂盒检测患者体内的 pf LDH抗原残留。 结果恶性疟原虫单一感染组与恶性疟原虫混合感染组在 pf LDH转阴时间上差异无统计学意义( P>0.05),两个青蒿琥酯注射治疗组与口服青蒿琥酯/阿莫地喹片治疗组在 pf LDH转阴时间上差异均有统计学意义( P<0.05),两个青蒿琥酯注射治疗组之间在 pf LDH转阴时间上差异无统计学意义(P>0.05)。 结论不同疟疾感染类型对于患者体内恶性疟原虫LDH抗原持续时间无影响，青蒿琥酯注射疗法较口服青蒿琥酯/阿莫地喹片疗法能更快地清除患者体内的恶性疟原虫LDH抗原。