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      Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

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          Abstract

          Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals using marine fish-derived proteins and peptides obtained from chemical or enzymatical hydrolysis of fish processing by-products has increased rapidly owing to their activities in antioxidation and tissue regeneration. Marine fish-derived collagen has been utilized for the development of cosmeceutical products due to its abilities in skin repair and tissue regeneration. Marine fish-derived peptides have also been utilized for various cosmeceutical applications due to their antioxidant, antimicrobial, and matrix metalloproteinase inhibitory activities. In addition, marine fish-derived proteins and hydrolysates demonstrated efficient anti-photoaging activity. The present review highlights and presents an overview of the current status of the isolation and applications of marine fish-derived proteins and peptides. This review also demonstrates that marine fish-derived proteins and peptides have high potential for biocompatible and effective cosmeceuticals.

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          Radical scavenging and antioxidant activity of tannic acid

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            Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

            The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse and hostile habitats, resulting in the biosynthesis of an array of secondary metabolites with specific activities. Several of these metabolites are high-value commercial products for the pharmaceutical and cosmeceutical industries. The aim of this review is to outline the paths of marine natural products discovery and development, with a special focus on the compounds that successfully reached the market and particularly looking at the approaches tackled by the pharmaceutical and cosmetic companies that succeeded in marketing those products. The main challenges faced during marine bioactives discovery and development programs were analyzed and grouped in three categories: biodiversity (accessibility to marine resources and efficient screening), supply and technical (sustainable production of the bioactives and knowledge of the mechanism of action) and market (processes, costs, partnerships and marketing). Tips to surpass these challenges are given in order to improve the market entry success rates of highly promising marine bioactives in the current pipelines, highlighting what can be learned from the successful and unsuccessful stories that can be applied to novel and/or ongoing marine natural products discovery and development programs.
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              Fish protein hydrolysates: production, biochemical, and functional properties.

              Considerable amounts of fish processing byproducts are discarded each year. By developing enzyme technologies for protein recovery and modification, production of a broad spectrum of food ingredients and industrial products may be possible. Hydrolyzed vegetable and milk proteins are widely used food ingredients. There are few hydrolyzed fish protein foods with the exception of East Asian condiments and sauces. This review describes various manufacturing techniques for fish protein hydrolysates using acid, base, endogenous enzymes, and added bacterial or digestive proteases. The chemical and biochemical characteristics of hydrolyzed fish proteins are discussed. In addition, functional properties of fish protein hydrolysates are described, including solubility, water-holding capacity, emulsification, and foam-forming ability. Possible applications of fish protein hydrolysates in food systems are provided, and comparison with other food protein hydrolysates where pertinent.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Mar Drugs
                Mar Drugs
                marinedrugs
                Marine Drugs
                MDPI
                1660-3397
                18 May 2017
                May 2017
                : 15
                : 5
                : 143
                Affiliations
                [1 ]Division of Bioengineering, Incheon National University, Incheon 406-772, Korea; venkatjchem@ 123456gmail.com
                [2 ]Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Riyadh, Post Box 153, AIKharj 11942, Saudi Arabia; drsanil@ 123456gmail.com
                [3 ]Department of Marine Life Sciences, Korean Maritime and Ocean University, 727 Taejong-ro, Yeongdo-Gu, Busan 49112, Korea
                Author notes
                [* ]Correspondence: sknkim@ 123456pknu.ac.kr (S.-K.K.); msshim@ 123456inu.ac.kr (M.S.S.); Tel.: +82-51-629-7550 (S.-K.K.); +82-32-835-8268 (M.S.S.)
                Article
                marinedrugs-15-00143
                10.3390/md15050143
                5450549
                28524092
                d79b54ff-6ec4-4097-8e69-42546b4535ff
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 28 February 2017
                : 11 May 2017
                Categories
                Review

                Pharmacology & Pharmaceutical medicine
                marine fish,cosmeceuticals,proteins,peptides,hydrolysates,collagen,antioxidant,anti-photoaging

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