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      The Myc/Max/Mad network and the transcriptional control of cell behavior.

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          Abstract

          The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression. A great deal of research indicates that the functions of the network play roles in cell proliferation, differentiation, and death. In this review we focus on the Myc and Mad protein families and attempt to relate their biological functions to their transcriptional activities and gene targets. Both Myc and Mad, as well as the more recently described Mnt and Mga proteins, form heterodimers with Max, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. Initial identification of target genes suggests that the network regulates genes involved in the cell cycle, growth, life span, and morphology. Because Myc and Mad proteins are expressed in response to diverse signaling pathways, the network can be viewed as a functional module which acts to convert environmental signals into specific gene-regulatory programs.

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          Author and article information

          Journal
          Annu Rev Cell Dev Biol
          Annual review of cell and developmental biology
          Annual Reviews
          1081-0706
          1081-0706
          2000
          : 16
          Affiliations
          [1 ] Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. cgrnador@fhcrc.org
          Article
          16/1/653
          10.1146/annurev.cellbio.16.1.653
          11031250
          d7a5482c-d1a2-4c16-8419-b4e597c72fc8
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