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      Non-contact weight measurement of flat-faced pharmaceutical tablets using terahertz transmission pulse delay measurements.

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          Abstract

          By measuring the time delay of a terahertz pulse traversing a tablet, and hence its effective refractive index, it is possible to non-invasively and non-destructively detect the weight of tablets made of microcrystalline cellulose (MCC). Two sets of MCC tablets were used in the study: Set A (training set) consisted of 13 tablets with nominally constant height but varying porosities, whereas Set B (test set) comprised of 21 tablets with nominally constant porosity but different heights. A linear correlation between the estimated absolute weight based on the terahertz measurement and the measured weight of both sets of MCC tablets was found. In addition, it was possible to estimate the height of the tablets by utilizing the estimated absolute weight and calculating the relative change of height of each tablet with respect to an ideal tablet. A good agreement between the experimental and the calculated results was found highlighting the potential of this technique for in-line sensing of the weight, porosity and the relative change in height of the tablets compared to a reference/ideal tablet. In this context, we propose a quantitative quality control method to assess the deviations in porosity of tablets immediately after compaction.

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          Author and article information

          Journal
          Int J Pharm
          International journal of pharmaceutics
          1873-3476
          0378-5173
          Dec 10 2014
          : 476
          : 1-2
          Affiliations
          [1 ] Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland; Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom. Electronic address: prince.bawuah@uef.fi.
          [2 ] Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
          [3 ] School of Pharmacy, Promis Centre, University of Eastern Finland, P.O. Box 1617, FI-70211, Finland.
          [4 ] Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom.
          Article
          S0378-5173(14)00682-6
          10.1016/j.ijpharm.2014.09.027
          25245546
          d7acad58-bbeb-490d-929a-31b7192f4ba3
          Copyright © 2014 Elsevier B.V. All rights reserved.
          History

          Compaction,Effective refractive index,High throughput technologies,Microcrystalline cellulose (MCC),Process analytical technology,Simulations,Tablet height,Tablet weight,Tablets,Terahertz spectroscopy

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