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      Discovery of swine as a host for the Reston ebolavirus.

      Science (New York, N.Y.)

      Animals, Antibodies, Viral, blood, Disease Outbreaks, veterinary, Disease Reservoirs, Ebolavirus, classification, genetics, immunology, isolation & purification, Filoviridae Infections, complications, epidemiology, virology, Hemorrhagic Fever, Ebola, Humans, Molecular Sequence Data, Philippines, Phylogeny, Porcine Reproductive and Respiratory Syndrome, Porcine respiratory and reproductive syndrome virus, Sus scrofa, Swine Diseases

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          Abstract

          Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

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          Journal
          19590002
          10.1126/science.1172705

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