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      Transient Ovarian Testosterone and Androstenedione Hypersecretion: A Cause of Virilization or Premature Pubarche in Prepubertal Girls

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          In 2 girls with signs of androgen overproduction, the usual causes were excluded. Patient 1 (3.6 years) presented with hypertrophy of the clitoris, patient 2 (7.8 years) with pubic and axillary hair. Urinary steroids and plasma dehydroepiandrosterone, 17-hydroxyprogesterone and estradiol were normal, but testosterone and androstenedione elevated in both cases. Echography showed polycystic ovaries. Testosterone and androstenedione returned to normal after laparotomy and removal of ovarian cysts in patient 1 and spontaneously in patient 2, in whom puberty started later appropriately for bone age.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          28 November 2008
          : 28
          : 1
          : 37-41
          Departments of Pediatrics and Pathology, University of Zürich, Switzerland
          180923 Horm Res 1987;28:37–41
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 5
          Pediatric Endocrinology


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