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      The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

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      Cell

      Elsevier BV

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          Abstract

          Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          April 2009
          April 2009
          : 137
          : 1
          : 32-45
          Article
          10.1016/j.cell.2009.03.023
          3016012
          19345185
          © 2009

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