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Abstract
Recent studies suggested that leptin in white adipose tissue (WAT) affected the sympathetic
out flow to several tissues. We examined whether elevations of renal sympathetic nerve
activity (RSNA) and blood pressure (BP) could be observed by leptin injection into
WAT in rats. Injections of leptin (10 and 100 ng/ml per kg) into WAT evoked the activation
of RSNA dose-dependently. Circulating sympathetic nerve activators, such as leptin,
insulin, glucose and lactate, were unchanged by any doses of leptin. In addition,
BP was not affected by leptin injections during a 90 min experimental period. These
data suggested that leptin activated the afferent nerves through the sensors in WAT,
resulting in elevation of RSNA.