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      Statin therapy is associated with reduced incidence of hypoxic hepatitis in critically ill patients.

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          Abstract

          Hypoxic hepatitis (HH) is a frequent and life-threatening complication associated with states of oxygen depletion in critically ill patients. Ischemia and reperfusion contribute to liver injury in HH. Experimental data suggest beneficial effects of statins in hepatic ischemia/reperfusion injury. This study was conducted to investigate whether statin treatment prior to intensive care unit (ICU) admission affects incidence rates and severity of HH.

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          Author and article information

          Journal
          J. Hepatol.
          Journal of hepatology
          1600-0641
          0168-8278
          Jun 2014
          : 60
          : 6
          Affiliations
          [1 ] Intensive Care Unit 13 H1, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.
          [2 ] Intensive Care Unit 13 I2, Department of Oncology and Infectious Diseases, Division of Internal Medicine I, Medical University of Vienna, Austria.
          [3 ] Intensive Care Unit 13 H3, Department of Cardiology, Division of Internal Medicine II, Medical University of Vienna, Austria.
          [4 ] Department of Gastroenterology and Hepatology, KA Rudolfstiftung, Austria.
          [5 ] Intensive Care Unit 13 H1, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address: v.fuhrmann@gmx.at.
          Article
          S0168-8278(14)00065-8
          10.1016/j.jhep.2014.01.019
          24509409
          Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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