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      Urinary GH Secretion Correlates with Plasma GH Levels during Sleep and GHRH Stimulation Tests but Not during the L-Dopa Stimulation Test in Prepubertal Children

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          In order to assess the value of urinary growth hormone (GH) as a reflection of central GH release, 42 prepubertal children with short stature and without organic disease were studied. A nocturnal GH profile and L-dopa and GH-releasing hormone (GHRH) tests were performed. Urinary GH was measured by means of a direct immunoradiometric method we have developed, using two monoclonal antibodies. Nocturnal urinary GH values correlated positively with plasma GH values expressed as the area under the curve (r = 0.76; p = 0.0001) or mean peak amplitude (r = 0.73; p = 0.0001). Also, urinary GH values correlated positively with peak plasma GH levels during the GHRH test (r = 0.64; p = 0.001). In contrast, no correlation was observed between peak plasma GH and urinary GH during the L-dopa test (r = 0.29; p = 0.11). This suggests a specific but as yet undetermined effect of L-dopa on urinary GH secretion.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 39
          : 1-2
          : 19-24
          aService de Biochimie-Hormonologie et, bService d’Endocrinologie Pediatrique, Hôpital Robert-Debré, Paris, France
          182689 Horm Res 1993;39:19–24
          © 1993 S. Karger AG, Basel

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          Pages: 6
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