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Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion.

Nature

Animals, chemistry, chemical synthesis, Pharmaceutical Preparations, Hydrogen, Hydrocarbons, Catalysis, Carbon, Biological Products

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      Abstract

      Novel reactions that can selectively functionalize carbon-hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon-hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C-H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C-H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.

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      Journal
      18216847
      10.1038/nature06485
      3033428

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