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      Análisis bibliométrico acerca de las investigaciones publicadas sobre Morus alba L. Translated title: Bibliometric analysis about the published studies on Morus alba L.

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          Abstract

          Resumen El objetivo de la investigación fue analizar la producción científica sobre Morus alba L. registrada en bases de datos internacionales durante el periodo 2013-2017. Se realizó una búsqueda en ScienceDirect, Springer, Redalyc y Scielo, de los artículos que contienen en el título la frase “Morus alba”; una vez eliminados los solapamientos se recuperaron 125 registros. Las variables evaluadas fueron: número de publicaciones por año, productividad por revista, productividad autoral, relación entre autores y palabras clave. El año más productivo fue el 2016 y la mayor cantidad de manuscritos se publicaron en la revista cubana Pastos y Forrajes. Las principales redes de colaboración se encontraron entre autores de Cuba, España, India y Corea del Sur. En el periodo, predominaron las investigaciones acerca de fitoquímica de esta planta para su uso en la salud animal y humana. La información científica acerca de M. alba en el periodo 2013-2017 es abundante y se evidencia un crecimiento en el número de publicaciones. El área temática más fortalecida corresponde a la fitoquímica y a sus potenciales usos en la salud animal y humana.

          Translated abstract

          Abstract The objective of the study was to analyze the scientific production on Morus alba L. recorded in international databases during the period 2013-2017. A search was carried out in ScienceDirect, Springer, Redalyc and Scielo, of the papers that have in the title the phrase “Morus alba”; once the overlapping cases were eliminated 125 records were recovered. The evaluated variables were: number of publications per year, productivity per journal, authors’ productivity, relation among authors and keywords. The most productive year was 2016 and the highest quantity of manuscripts was published in the Cuban journal Pastos y Forrajes. The main collaboration networks were found among authors from Cuba, Spain, India and South Korea. In the period, the research about the phytochemical indicators of this plant for its use in animal and human health prevailed. The scientific information about M. alba in the period 2013-2017 is abundant and a growth in the number of publications is shown. The most enhanced thematic area corresponds to its phytochemistry and its potential uses in animal and human health.

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          Phytochemistry, pharmacology, and clinical trials of Morus alba.

          The present review is aimed at providing a comprehensive summary on the botany, utility, phytochemistry, pharmacology, and clinical trials of Morus alba (mulberry or sang shu). The mulberry foliage has remained the primary food for silkworms for centuries. Its leaves have also been used as animal feed for livestock and its fruits have been made into a variety of food products. With flavonoids as major constituents, mulberry leaves possess various biological activities, including antioxidant, antimicrobial, skin-whitening, cytotoxic, anti-diabetic, glucosidase inhibition, anti-hyperlipidemic, anti-atherosclerotic, anti-obesity, cardioprotective, and cognitive enhancement activities. Rich in anthocyanins and alkaloids, mulberry fruits have pharmacological properties, such as antioxidant, anti-diabetic, anti-atherosclerotic, anti-obesity, and hepatoprotective activities. The root bark of mulberry, containing flavonoids, alkaloids and stilbenoids, has antimicrobial, skin-whitening, cytotoxic, anti-inflammatory, and anti-hyperlipidemic properties. Other pharmacological properties of M. alba include anti-platelet, anxiolytic, anti-asthmatic, anthelmintic, antidepressant, cardioprotective, and immunomodulatory activities. Clinical trials on the efficiency of M. alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted. The phytochemistry and pharmacology of the different parts of the mulberry tree confer its traditional and current uses as fodder, food, cosmetics, and medicine. Overall, M. alba is a multi-functional plant with promising medicinal properties.
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            Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry ( Morus alba L.) leaves

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              Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling

              Background Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of M. alba on leukocyte migration, one key step in inflammation. Methods Gas chromatography-mass spectrometry (GC-MS) and cluster analyses of supercritical CO2 extracts of three Morus species were performed for chemotaxonomy-aided plant authentication. Phytochemistry and CXCR4-mediated chemotaxis assays were used to characterize the chemical and biological properties of M. alba and its active compound, oxyresveratrol. fluorescence-activated cell sorting (FACS) and Western blot analyses were conducted to determine the mode of action of oxyresveratrol. Results Chemotaxonomy was used to help authenticate M. alba. Chemotaxis-based isolation identified oxyresveratrol as an active component in M. alba. Phytochemical and chemotaxis assays showed that the crude extract, ethyl acetate fraction and oxyresveratrol from M. alba suppressed cell migration of Jurkat T cells in response to SDF-1. Mechanistic study indicated that oxyresveratrol diminished CXCR4-mediated T-cell migration via inhibition of the MEK/ERK signaling cascade. Conclusions A combination of GC-MS and cluster analysis techniques are applicable for authentication of the Morus species. Anti-inflammatory benefits of M. alba and its active compound, oxyresveratrol, may involve the inhibition of CXCR-4-mediated chemotaxis and MEK/ERK pathway in T and other immune cells.
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                Author and article information

                Journal
                pyf
                Pastos y Forrajes
                Pastos y Forrajes
                Estación Experimental de Pastos y Forrajes "Indio Hatuey" (Matanzas, , Cuba )
                0864-0394
                2078-8452
                March 2019
                : 42
                : 1
                : 81-87
                Affiliations
                [1] Holguín orgnameUniversidad de Holguín Cuba
                [2] Bayamo, Granma orgnameInstituto de Investigaciones Agropecuarias Jorge Dimitrov Cuba
                [3] Sancti Spíritus orgnameEstación Experimental de Pastos y Forrajes en Sancti Spíritus Cuba
                Article
                S0864-03942019000100081 S0864-0394(19)04200100081
                d8080e1a-372e-469a-9cb2-f4a2b6e0b412

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 21 December 2018
                : 17 October 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 24, Pages: 7
                Product

                SciELO Cuba

                Categories
                ARTÍCULO CIENTIFICO

                bibliometry,scientific information,animal production,forages,bibliometría,información científica,producción animal,forrajes

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