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      ‘Clean Dialysate’ Requires Not Only Lower Levels of Endotoxin but Also Sterility of Dilution Water

      Blood Purification

      S. Karger AG

      Sterilization, Clean dialysate, Dilution water (for dialysate), Endotoxin, Bacterial growth

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          Abstract

          Clean dialysate should be used in dialysis with a high-flux dialysis membrane to avoid contamination of endotoxin into blood circuits. For this purpose, we should not only clean up the end stream dialysate by endotoxin-cut filters, but also prevent bacterial growth in dilution water lines. Delivery lines of the prepared dialysate from a central dialysate-supplying machine are sterilized in all dialysis facilities, but those of the dilution water in cases of using personal dialysis machines are not sterilized in most facilities in Japan. In our dialysis department, the endotoxin level in the dilution water lines decreased to <50 EU/l in 3 weeks by sterilization with a low concentration of sodium hypochlorite (30–100 ppm) once a week from the peak level of >1,000 EU/l just after the start of sterilization.

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          Author and article information

          Journal
          BPU
          Blood Purif
          10.1159/issn.0253-5068
          Blood Purification
          S. Karger AG
          978-3-8055-7886-8
          978-3-318-01189-0
          0253-5068
          1421-9735
          2004
          January 2005
          27 January 2005
          : 22
          : Suppl 2
          : 78-80
          Affiliations
          Social Insurance Chuo General Hospital, Tokyo, Japan
          Article
          81880 Blood Purif 2004;22(suppl 2):78–80
          10.1159/000081880
          15655329
          © 2004 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 1, References: 4, Pages: 3
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/81880
          Categories
          Luncheon Seminar

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