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Abstract
A multicenter, randomized double-blind study was carried out in 203 patients with
metastatic prostate cancer, in order to compare the efficacy of complete suppression
of androgens achieved with surgical castration and nilutamide (Anandron), 100 mg t.i.d.
The combined therapy was well-tolerated by patients, and they noted a better relief
of bone pain after six months than those in the control group. There was a greater
number of favorable responses in the combined treatment group. In addition, despite
a similar median progression-free actuarial rate, the combined treatment (nilutamide
plus orchiectomy) offered an improved survival time over orchiectomy alone.