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The functions of animal microRNAs.

Nature

Substrate Specificity, genetics, Multigene Family, metabolism, MicroRNAs, Genomics, Gene Expression Regulation, Animals

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      Abstract

      MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

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      Journal
      10.1038/nature02871
      15372042

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