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      A natural polymorphism in  -lactamase is a global suppressor

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      Proceedings of the National Academy of Sciences

      Proceedings of the National Academy of Sciences

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          Most cited references 15

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          [19] Rapid and efficient site-specific mutagenesis without phenotypic selection

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            In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.

            Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhibitors has been limited by the emergence of resistant viral variants. Similarly, variants expressing resistance to protease inhibitors have been derived in cell culture. We now report the characterization of resistant variants isolated from patients undergoing therapy with the protease inhibitor MK-639 (formerly designated L-735,524). Five of these variants, isolated from four patients, exhibited cross-resistance to all members of a panel of six structurally diverse protease inhibitors. This suggests that combination therapy with multiple protease inhibitors may not prevent loss of antiviral activity resulting from resistance selection. In addition, previous therapy with one compound may abrogate the benefit of subsequent treatment with a second inhibitor.
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              Deciphering the message in protein sequences: tolerance to amino acid substitutions.

              An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.
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                Author and article information

                Journal
                Proceedings of the National Academy of Sciences
                Proceedings of the National Academy of Sciences
                Proceedings of the National Academy of Sciences
                0027-8424
                1091-6490
                August 05 1997
                August 05 1997
                : 94
                : 16
                : 8801-8806
                Article
                10.1073/pnas.94.16.8801
                © 1997
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