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      Effect of Sex Hormones on Rabbit Arterial Subendothelial Connective Tissue

      Journal of Vascular Research

      S. Karger AG

      Arteries, Subendothelium, Sex hormones, Hemostasis

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          Abstract

          The effect of sex hormones on subendothelial connective tissue in rabbit arteries was sought, and striking morphological alterations were noted after prolonged treatment. Depot preparations of testosterone cypionate, 100 mg/week, or estradiol cypionate, 200 µg/week, were injected intramuscularly into intact adult New Zealand male rabbits for 8–16 weeks. The iliac arteries were prepared for electron-microscopic examination from five rabbits in each treatment group and in four normal male rabbits. Thin sections were prepared from three randomly selected cross-sectional tissue blocks for each animal. A minimum of 7 µm of vessel circumference was studied in each block. Selection of an area for electron-microscopic examination was random, except that those sites in which the internal elastic lamina showed fragmentation were discarded. Electron micrographs at a single final magnification were evaluated ‘blind’ by several observers for qualitative difference in subendothelial constituents. In the control group, the subendothelium contained moderate numbers of elastin-associated microfibrils (MF); all the rabbits given testosterone consistently showed significantly fewer MF than the control. In contrast, rabbits given estradiol all had significantly greater numbers of MF. Statistical analysis of variance showed these difference to be significant at p < 0.001.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1975
          1975
          18 September 2008
          : 12
          : 3
          : 161-165
          Affiliations
          Division of Hematology, Department of Medicine, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, Bronx, N.Y.
          Article
          158047 Blood Vessels 1975;12:161–165
          10.1159/000158047
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
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