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      Requesting iodine supplementation in children on parenteral nutrition

      , , ,
      Clinical Nutrition
      Elsevier BV

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          Abstract

          Iodine supplementation of parenterally fed infants recommended by ESPGHAN is 1 microg/kg/day. To assess nutritional and thyroid status of children on parenteral nutrition (PN) through urinary iodine concentration (UIC). Children (1-17 yrs), undergoing PN and receiving an iodine supply of 1 microg/kg/day, were enrolled from 2000 to 2007. We observed 15 children (10 males, mean age 76.53+/-60.4 months) on PN from 14 to 84 weeks (mean 38.5+/-21.4). Ten were on TPN and five on PPN; nine had short bowel syndrome (SBS) and six had other intestinal diseases requiring PN. Iodine supply in TPN ranged between 1 and 1.6 microg/kg/day (mean 1.1+/-0.3 microg/kg/day), while in PPN it ranged from 2.3 to 2.8 microg/kg/day (mean 2.6+/-0.7 microg/kg/day). We found an inverse correlation between duration of PN in months and UIC (P=0.05). Four weeks after PN onset, UIC<100 microg/L was found in all SBS patients and 3/6 non-SBS patients (P<0.05). After 12 weeks, 8/15 (53%) patients had UIC<50 microg/L, but thyroxine, TSH and thyroid volume remained unchanged. A PN iodine supply of 1 microg/kg/day may be suboptimal. Higher supplies should be evaluated in controlled trials.

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          Author and article information

          Journal
          Clinical Nutrition
          Clinical Nutrition
          Elsevier BV
          02615614
          June 2009
          June 2009
          : 28
          : 3
          : 256-259
          Article
          10.1016/j.clnu.2009.02.005
          19269721
          d84c7e1a-1645-40e8-9b3e-078ac69e6116
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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