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Abstract
Iodine supplementation of parenterally fed infants recommended by ESPGHAN is 1 microg/kg/day.
To assess nutritional and thyroid status of children on parenteral nutrition (PN)
through urinary iodine concentration (UIC).
Children (1-17 yrs), undergoing PN and receiving an iodine supply of 1 microg/kg/day,
were enrolled from 2000 to 2007.
We observed 15 children (10 males, mean age 76.53+/-60.4 months) on PN from 14 to
84 weeks (mean 38.5+/-21.4). Ten were on TPN and five on PPN; nine had short bowel
syndrome (SBS) and six had other intestinal diseases requiring PN. Iodine supply in
TPN ranged between 1 and 1.6 microg/kg/day (mean 1.1+/-0.3 microg/kg/day), while in
PPN it ranged from 2.3 to 2.8 microg/kg/day (mean 2.6+/-0.7 microg/kg/day). We found
an inverse correlation between duration of PN in months and UIC (P=0.05). Four weeks
after PN onset, UIC<100 microg/L was found in all SBS patients and 3/6 non-SBS patients
(P<0.05). After 12 weeks, 8/15 (53%) patients had UIC<50 microg/L, but thyroxine,
TSH and thyroid volume remained unchanged.
A PN iodine supply of 1 microg/kg/day may be suboptimal. Higher supplies should be
evaluated in controlled trials.