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      Immunological goings-on in visceral adipose tissue.

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      Cell metabolism

      Elsevier BV

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          Abstract

          Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.

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          Author and article information

          Journal
          Cell Metab.
          Cell metabolism
          Elsevier BV
          1932-7420
          1550-4131
          Jun 04 2013
          : 17
          : 6
          Affiliations
          [1 ] Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. cbdm@hms.harvard.edu
          Article
          S1550-4131(13)00198-8 NIHMS565242
          10.1016/j.cmet.2013.05.008
          4264591
          23747244

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